Elemental tomography of cancer-cell spheroids reveals incomplete uptake of both Platinum(II) and Platinum(IV) complexes

被引：48

作者：

Alderden, Rebecca A.

Mellor, Howard R.

Modok, Szabolcs

Hall, Matthew D.

Sutton, Stephen R.

Newville, Matthew G.

Callaghan, Richard

Hambley, Trevor W. ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem, Ctr Heavy Met Res, Sydney, NSW 2006, Australia

[2] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Lab Sci, Oxford OX3 9DU, England

[3] Univ Chicago, Dept Geophys Sci, Chicago, IL 60637 USA

[4] Univ Chicago, Ctr Adv Radiat Sources, Chicago, IL 60637 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 44期

关键词：

D O I：

10.1021/ja076281t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The limited penetration of cytotoxic drugs into tumors is a significant contributing factor to the limited effectiveness of cancer chemotherapy. Here we have shown that X-ray fluorescence microtomography is a suitable technique for imaging the distribution of Pt drugs within multicellular tumor spheroids, models of solid tumors. This has revealed that there is no significant difference between the distributions of the range of Pt(II) and Pt(IV) complexes investigated, suggesting that complexes that are more resistant to cellular uptake may be needed to ensure more complete distribution throughout a tumor.

引用

页码：13400 / +

页数：3

共 24 条

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