Antiinflammatory activity of the pectic polysaccharide from Comarum palustre

被引：41

作者：

Popov, SV ^{[1
]}

Popova, GY ^{[1
]}

Ovodova, RG ^{[1
]}

Ovodov, YS ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Physiol, Komi Sci Ctr, Urals Branch, Syktyvkar 167982, Republic Komi, Russia

来源：

FITOTERAPIA | 2005年 / 76卷 / 3-4期

基金：

俄罗斯基础研究基金会;

关键词：

Comarum palustre; comaruman; antiinflammatory; leukocyte adhesion;

D O I：

10.1016/j.fitote.2005.03.018

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A pectic polysaccharide named comaruman (CP) was extracted from the aerial part of Comarum palustre with 0.7% aqueous ammonium oxalate and subsequent precipitation with ethanol. Oral administration of comaruman (5-100 mg/kg) was found to reduce a paw edema observed 24 h after injection of 2% formalin in mice. A fraction of comaruman (CP-H9) exhibited a similar anti inflammatory activity. Comaruman, CP deprived of lipid, CP purified by proteins and CP fractions obtained with acidic hydrolysis inhibit spontaneous and phorbol-12-myristate-13-acetateactivated adhesion of peritoneal leukocytes in vitro. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：281 / 287

页数：7

共 12 条

[1] COLORIMETRIC METHOD FOR DETERMINATION OF SUGARS AND RELATED SUBSTANCES [J].