A practical preparation of diisopropyl phosphoryl protected amino acids.

被引：24

作者：

Brands, KMJ ^{[1
]}

Wiedbrauk, K ^{[1
]}

Williams, JM ^{[1
]}

Dolling, UH ^{[1
]}

Reider, PJ ^{[1
]}

机构：

[1] Merck & Co Inc, Merck Sharp & Dohme Res Labs, Det Proc Res, Rahway, NJ 07065 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 52期

关键词：

amino acids and derivatives; phosphoramidates; protecting groups;

D O I：

10.1016/S0040-4039(98)02300-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Diisopropyl phosphoryl protected amino acids can be prepared in high yield and without racemization by slow addition of sodium hypochlorite to a solution of the amino acid and diisopropylphosphite in water while carefully maintaining a constant pH via the addition of sodium hydroxide. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：9583 / 9586

页数：4

共 13 条

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