Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridine phosphorylase

被引：12

作者：

Cuq, P

Rouquet, C

Evrard, A

Ciccolini, J

Vian, L

Cano, JP

机构：

[1] Fac Pharm Montpellier, Lab Toxicol Medicament, F-34060 Montpellier 02, France

[2] Lab Toxicocinet & Pharmacocinet, F-13385 Marseille, France

来源：

BRITISH JOURNAL OF CANCER | 2001年 / 84卷 / 12期

关键词：

uridine phosphorylase; breast cancer; 5-FU; 5 ' DFUR; cancer gene therapy;

D O I：

10.1054/bjoc.2001.1833

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The relationship between uridine phosphorylase (UP) expression level in cancer cells and the tumour sensitivity to fluoropyrimidines is unclear. In this study, we found that UP overexpression by gene transfer, and the subsequent efficient metabolic activation of 5-fluorouracil (5-FU) by the ribonucleotide pathway, does not increase the fluoropyrimidine sensitivity of MCF-7 human cancer cells. (C) 2001 Cancer Research Campaign.

引用

页码：1677 / 1680

页数：4

共 21 条

[1] Thymidine phosphorylase: its role in sensitivity and resistance to anticancer drugs [J].