Assignment of absolute configuration of the alpha,beta-unsaturated gamma-methyl-gamma-lactone of the annonaceous acetogenins by a simple enzymatic method

被引：18

作者：

Duret, P

Waechter, AI

Figadere, B

Hocquemiller, R

Cave, A

Pierard, C

Peres, M

机构：

[1] UNIV PARIS SUD,FAC PHARM,CNRS,LAB PHARMACOGNOISE,F-92296 CHATENAY MALABRY,FRANCE

[2] INST MED AEROSPATIALE,DEPT NEUROPHYSIOL AEROSPATIALE,LAB RMN,F-91223 BRETIGNY SUR ORGE,FRANCE

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 39期

关键词：

D O I：

10.1016/0040-4039(96)01592-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The absolute configuration of the C-36 or C-34 chiral centers of Annonaceous acetogenins has been determined by simple enzymatic method focusing on the HPLC detection of NADH issued from the enzymatic oxidation of L- or D-lactic acid (obtained by oxidative cleavage of the terminal alpha,beta-unsaturated gamma-methyl-gamma-lactone) to pyruvic acid by lactate dehydrogenase. Copyright (C) 1996 Published by Elsevier Science Ltd

引用

页码：7043 / 7046

页数：4

共 12 条

[1]

CAVE A, 1996, PROGR CHEM ORGANIC N

[2]

Gutmann I., 1974, Methods of Enzymatic Analysis, P1464

[3] DETERMINATION OF THE ABSOLUTE-CONFIGURATION OF ANNONIN-I, A BIOACTIVE NATURAL ACETOGENIN FROM ANNONA-SQUAMOSA [J].