Long noncoding RNA CMPK2 promotes colorectal cancer progression by activating the FUBP3-c-Myc axis

被引：53

作者：

Gao, Qingzu ^{[1
,2
,3
]}

Zhou, Rui ^{[1
,3
]}

Meng, Yuan ^{[1
,4
]}

Duan, Rongfei ^{[5
]}

Wu, Ling ^{[1
,3
]}

Li, Rui ^{[1
,3
]}

Deng, Fengliu ^{[1
,3
]}

Lin, Chuang ^{[1
]}

Zhao, Liang ^{[1
,3
]}

机构：

[1] Southern Med Univ, Nanfang Hosp, Dept Pathol, Guangzhou, Peoples R China

[2] Xinxiang Med Univ, Dept Pathol, Affiliated Hosp 1, Xinxiang, Henan, Peoples R China

[3] Southern Med Univ, Sch Basic Med Sci, Dept Pathol, Guangzhou, Peoples R China

[4] Second Peoples Hosp Longgang Dist, Dept Pathol, Shenzhen, Peoples R China

[5] Xinxiang Med Univ, Dept Endocrinol, Affiliated Hosp 1, Guangzhou, Peoples R China

来源：

ONCOGENE | 2020年 / 39卷 / 19期

基金：

中国国家自然科学基金;

关键词：

FAR UPSTREAM ELEMENT; C-MYC; TRANSCRIPTION; PROTEINS; LNCRNA; LIM;

D O I：

10.1038/s41388-020-1266-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Long noncoding RNAs (lncRNAs) have been shown to play crucial roles in cancer long noncoding RNAs (lncRNAs) have been known to play crucial roles in cancer development and progression by regulating chromatin dynamics and gene expression. However, only a few lncRNAs with annotated functions in the progression of colorectal cancer (CRC) have been identified to date. In the present study, the expression of lncCMPK2 was upregulated in CRC tissues and positively correlated with clinical stages and lymphatic metastasis. The overexpression of lncCMPK2 promoted the proliferation and cell cycle transition of CRC cells. Conversely, the silencing of lncCMPK2 restricted cell proliferation both in vitro and in vivo. lncCMPK2 was localized to the nucleus of CRC cells, bound to far upstream element binding protein 3 (FUBP3), and guided FUBP3 to the far upstream element (FUSE) of the c-Myc gene to activate transcription. lncCMPK2 also stabilized FUBP3. These results provide novel insights into the functional mechanism of lncCMPK2 in CRC progression and highlight its potential as a biomarker of advanced CRC and therapeutic target.

引用

页码：3926 / 3938

页数：13

共 41 条

[1]

Long Noncoding RNA TARID Directs Demethylation and Activation of the Tumor Suppressor TCF21 via GADD45A [J].