Hypoxia:: the tumor's gateway to progression along the angiogenic pathway

被引：110

作者：

Brahimi-Horn, C ^{[1
]}

Berra, E ^{[1
]}

Pouysségur, J ^{[1
]}

机构：

[1] Ctr Antoine Lacassagne, CNRS UMR 6543, Inst Signaling Dev Biol & Canc Res, F-06189 Nice, France

来源：

TRENDS IN CELL BIOLOGY | 2001年 / 11卷 / 11期

关键词：

D O I：

10.1016/S0962-8924(01)82185-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Decreased aerobic (hypoxic) conditions in tumors induce the release of cytokines that promote vascularization and thereby enhance tumor growth and metastasis. Recent major advances have provided insight into the role hypoxia plays in cancer biology. The domain structure of the hypoxia-inducible factor 1 alpha (HIF-1 alpha) has been elucidated, as has the mechanism by which stabilization of HIF-1 alpha leads to initiation of the transcription of target genes involved in growth of blood vessels.

引用

页码：S32 / S36

页数：5

共 41 条

[1] Tracheal development and the von Hippel-Lindau tumor suppressor homolog in Drosophila
Adryan, B
Decker, HJH
Papas, TS
Hsu, T
[J]. ONCOGENE, 2000, 19 (24) : 2803 - 2811
[2] MAP kinases and hypoxia in the control of VEGF expression
Berra, E
Pagès, G
Pouysségur, J
[J]. CANCER AND METASTASIS REVIEWS, 2000, 19 (1-2) : 139 - 145
[3] Hypoxia-inducible factor-1α (HIF-1α) escapes O2-driven proteasomal degradation irrespective of its subcellular localization:: nucleus or cytoplasm
Berra, E
Roux, D
Richard, DE
Pouysségur, J
[J]. EMBO REPORTS, 2001, 2 (07) : 615 - 620
[4] HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1α degradation
Berra, E
Richard, DE
Gothié, E
Pouysségur, J
[J]. FEBS LETTERS, 2001, 491 (1-2) : 85 - 90
[5] Exploiting the hypoxic cancer cell: mechanisms and therapeutic strategies
Brown, JM
[J]. MOLECULAR MEDICINE TODAY, 2000, 6 (04): : 157 - 162
[6] Angiogenesis in cancer and other diseases
Carmeliet, P
Jain, RK
[J]. NATURE, 2000, 407 (6801) : 249 - 257
[7] Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
Cockman, ME
Masson, N
Mole, DR
Jaakkola, P
Chang, GW
Clifford, SC
Maher, ER
Pugh, CW
Ratcliffe, PJ
Maxwell, PH
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (33) : 25733 - 25741
[8] Molecular mechanisms of transcription activation by HLF and HIF1α in response to hypoxia:: their stabilization and redox signal-induced interaction with CBP/p300
Ema, M
Hirota, K
Mimura, J
Abe, H
Yodoi, J
Sogawa, K
Poellinger, L
Fujii-Kuriyama, Y
[J]. EMBO JOURNAL, 1999, 18 (07) : 1905 - 1914
[9] Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice
Gnarra, JR
Ward, JM
Porter, FD
Wagner, JR
Devor, DE
Grinberg, A
EmmertBuck, MR
Westphal, H
Klausner, RD
Linehan, WM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (17) : 9102 - 9107
[10] GOTHIE E, IN PRESS MED SCI

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