Impact of growth plate senescence on catch-up growth and epiphyseal fusion

被引:30
作者
Nilsson, O
Baron, J
机构
[1] NICHD, Nihon Univ, CRC, Bethesda, MD 20892 USA
[2] NICHHD, Dev Endocrinol Branch, NIH, Bethesda, MD 20892 USA
关键词
longitudinal bone growth; growth plate; senescence; epiphyseal fusion; catch-up growth;
D O I
10.1007/s00467-004-1689-4
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
In mammals, longitudinal bone growth occurs rapidly in prenatal and early postnatal life, but then slows and eventually ceases. This deceleration, which reflects a decline in chondrocyte proliferation, was previously attributed to a hormonal or other systemic mechanism. However, new evidence suggests that it is due to a local mechanism within the growth plate. In particular, recent findings suggest that growth plate chondrocytes have a finite proliferative capacity that is gradually exhausted, causing growth to slow and finally stop. This concept has provided insight into clinical phenomena including catch-up growth after transient growth inhibition, catch-down growth after transient estrogen exposure, and epiphyseal fusion.
引用
收藏
页码:319 / 322
页数:4
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