In vitro carbonated apatite precipitation on biphasic calcium phosphate pellets presenting various HA/β-TCP ratios

被引：16

作者：

Bouler, JM ^{[1
]}

Daculsi, G ^{[1
]}

机构：

[1] Fac Chirurg Dent, Ctr Rech, INSERM 99 03, FR-44042 Nantes 1, France

来源：

BIOCERAMICS | 2000年 / 192-1卷

关键词：

biomaterials; biphasic calcium phosphate ceramics; carbonated apatites;

D O I：

10.4028/www.scientific.net/KEM.192-195.119

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 [材料科学与工程]; 080502 [材料学];

摘要：

To study the influence of calcium phosphate ceramic composition on biological apatite formation, pellets made of hydroxyapatite (IIA), p-tricalcium phosphate (P-TCP) and two types of biphasic calcium phosphates (BCP) with HA/beta -TCP ratios of 25/75 and 75/25 were incubated in cell medium for 48 hours. Then pellets were removed from wells and surfaces were analyzed in Scanning Electron Microscopy equipped with an image analysis system and in Transmission Electron Microscopy (TEM) equipped with Electron microprobe analysis (EDX). pH and calcium concentrations were also measured in incubation wells. Newly formed carbonated apatite crystals were observed at the surface of all the pellets. However : 1. the amount of precipitated crystals was twice lower for pure P-TCP 2. the apatite formation occured faster for biphasic pellets (HA/beta -TCP mixtures) Knowing that the biological apatite layer is involved in cells adhesion, these results may explain partially in vivo performances of biphasic calcium phosphate ceramics as bone substitutes.

引用

页码：119 / 122

页数：4

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