Negative regulation of cytokine signaling and immune responses by SOCS proteins

被引：142

作者：

Yoshimura, A ^{[1
]}

Nishinakamura, H ^{[1
]}

Matsumura, Y ^{[1
]}

Hanada, T ^{[1
]}

机构：

[1] Kyushu Univ, Med Inst Bioregulat, Div Mol & Cellular Immunol, Fukuoka 812, Japan

来源：

ARTHRITIS RESEARCH & THERAPY | 2005年 / 7卷 / 03期

关键词：

D O I：

10.1186/ar1741

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytokines exert their biological functions through JAKs (Janus tyrosine kinases) and STAT (signal transduction and activators of transcription) transcription factors. CIS (cytokine-inducible SH2 (Src homology 2) protein) and SOCS (suppressor of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine-mediated homeostasis, including innate and adaptive immunity. In this review we focus on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in immune regulation and inflammatory diseases including rheumatoid arthritis.

引用

页码：100 / 110

页数：11

共 100 条

[1] Suppressors of cytokine signalling (SOCS) in the immune system [J].

Alexander, WS .

NATURE REVIEWS IMMUNOLOGY, 2002, 2 (06) :410-416

[2] The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immuneresponse [J].

Alexander, WS ;

Hilton, DJ .

ANNUAL REVIEW OF IMMUNOLOGY, 2004, 22 :503-529

[3] SOCS1 is a critical inhibitor of interferon γ signaling and prevents the potentially fatal neonatal actions of this cytokine [J].

Alexander, WS ;

Starr, R ;

Fenner, JE ;

Scott, GL ;

Handman, E ;

Sprigg, NS ;

Corbin, JE ;

Cornish, AL ;

Darwiche, R ;

Owczarek, CM ;

Kay, TWH ;

Nicola, NA ;

Hertzog, PJ ;

Metcalf, D ;

Hilton, DJ .

CELL, 1999, 98 (05) :597-608

[4] A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis [J].

Atsumi, T ;

Ishihara, K ;

Kamimura, D ;

Ikushima, H ;

Ohtani, T ;

Hirota, S ;

Kobayashi, H ;

Park, SJ ;

Saeki, Y ;

Kitamura, Y ;

Hirano, T .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (07) :979-990

[5] Suppressor of cytokine signaling (SOCS) proteins indirectly regulate toll-like receptor signaling in innate immune cells [J].

Baetz, A ;

Frey, M ;

Heeg, K ;

Dalpke, AH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (52) :54708-54715

[6] Promoter hypermethylation of tumor-related genes in the progression of colorectal neoplasia [J].

Bai, AHC ;

Tong, JHM ;

To, KF ;

Chan, MWY ;

Man, EPS ;

Lo, KW ;

Lee, JFY ;

Sung, JJY ;

Leung, WK .

INTERNATIONAL JOURNAL OF CANCER, 2004, 112 (05) :846-853

[7] SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985 [J].

Bjorbæk, C ;

Lavery, HJ ;

Bates, SH ;

Olson, RK ;

Davis, SM ;

Flier, JS ;

Myers, MG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (51) :40649-40657

[8] LPS and TNFα induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages [J].

Bode, JG ;

Nimmesgern, A ;

Schmitz, J ;

Schaper, F ;

Schmitt, M ;

Frisch, W ;

Hussinger, D ;

Heinrich, PC ;

Graeve, L .

FEBS LETTERS, 1999, 463 (03) :365-370

[9] Constitutive SOCS-3 expression protects T-cell lymphoma against growth inhibition by IFNα [J].

Brender, C ;

Lovato, P ;

Sommer, VH ;

Woetmann, A ;

Mathiesen, AM ;

Geisler, C ;

Wasik, M ;

Odum, N .

LEUKEMIA, 2005, 19 (02) :209-213

[10] SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function [J].

Brender, C ;

Columbus, R ;

Metcalf, D ;

Handman, E ;

Starr, R ;

Huntington, N ;

Tarlinton, D ;

Odum, N ;

Nicholson, SE ;

Nicola, NA ;

Hilton, DJ ;

Alexander, WS .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (13) :6094-6103

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