Novel antibacterial triterpenoid from Combretum padoides [Combretaceae]

被引：10

作者：

Angeh, Jeremiah E.

Huang, Xueshi

Swan, Gerry E.

Moellman, Ute

Sattler, Isabel

Eloff, Jacobus N. ^{[1
]}

机构：

[1] Univ Pretoria, Fac Vet Sci, Dept Paraclin Sci, Phytomed Program, Onderstepoort, South Africa

[2] Leibniz Inst Nat Prod Res & Infect Biol, D-07745 Jena, Germany

来源：

ARKIVOC | 2007年

关键词：

Combretum padoides; Combretaceae; triterpenoid; antibacterial; cytoxicity;

D O I：

10.3998/ark.5550190.0008.913

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The dichloromethane extract of C. padoides leaves was subjected to antibacterial activity guided fractionation against Staphylococcus aureus to afford a new oleanene-type triterpenoid glycoside identified as 1 alpha, 23 beta-dihydroxy-12-oleanen-29-oic acid-23 beta-O-alpha-4-acetylrhamnopyranoside (1) together with two known compounds 1,22- dihydroxy- 12- oleanen-30-oic acid (2) and 24ethylcholesta-7,22,25- trien- O-beta-D-glucopyranoside (3) on the basis of 1D NMR, 2D NMR and ESI-MS analysis. Compounds 1 and 2 had a reasonable antibacterial activity [MIC of 0.031 and 0.063 mg/ ml] against S. aureus and Escherichia coli. All compounds were non- cytotoxic. The results indicate that pentacyclic triterpenes from C. padoides have some antibacterial activity with no cytotoxic activity.

引用

页码：113 / 120

页数：8

共 15 条

[1]

ANGEH JE, 2007, IN PRESS J ETHNOPHAR, DOI DOI 10.1016/J.JEP2006.09.002

[2]

Atta-Ur-Rahman,, 1997, PHYTOCHEMISTRY, V46, P1215, DOI 10.1016/S0031-9422(97)00444-5

[3]

BEGUE WJ, 1972, J CHROMATOGR, V64, P182

[4]

CARR JD, 1997, S AFRICAN J BOT, V53, P173