Widespread brain distribution of mRNA encoding the orphan neurotransmitter transporter v7-3

被引：19

作者：

Inoue, K

Sato, K

Tohyama, M

Shimada, S

Uhl, GR

机构：

[1] NATL INST DRUG ABUSE,INTRAMURAL RES PROGRAM,MOL NEUROBIOL BRANCH,BALTIMORE,MD 21224

[2] OSAKA UNIV,SCH MED,DEPT ANAT & NEUROSCI,OSAKA,JAPAN

[3] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL & NEUROSCI,BALTIMORE,MD 21224

来源：

MOLECULAR BRAIN RESEARCH | 1996年 / 37卷 / 1-2期

基金：

美国国家卫生研究院;

关键词：

sodium- and chloride-dependent neurotransmitter transporter family; v7-3; mRNA expression; hybridization; in situ; widespread brain distribution;

D O I：

10.1016/0169-328X(95)00298-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Orphan transporter v7-3 is a member of a new subfamily of Na+, Cl- dependent neurotransmitter transporters with two large extracellular loops. Distribution of v7-3 mRNA was investigated in the rat brain. In situ hybridization study revealed that v7-3 mRNA was widely distributed in the rat central nervous system, including the olfactory bulb, the hypothalamus, the cerebral cortex, the hippocampus, and the cerebellum. In addition, intense v7-3 mRNA expression was found in the motor nuclei including the oculomotor nucleus, abducens nucleus, trigeminal motor nucleus, facial nucleus, hypoglossal nucleus and ventral horn of spinal cord. Intense hybridization signals were also observed in the nuclei containing monoaminergic neurons, such as locus coeruleus, the substantia nigra pars compacta, the ventral tegmental area, the dorsal raphe nucleus and the median raphe nucleus. This multifocal and broad nature of the v7-3 distribution suggests widespread roles for this gene product in neurons mediating several important brain function.

引用

页码：217 / 223

页数：7

共 19 条

[1] CLONING AND EXPRESSION OF A FUNCTIONAL SEROTONIN TRANSPORTER FROM RAT-BRAIN [J].