Fitness and freezing: vector biology and human health

被引：13

作者：

Dumler, J. Stephen ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Pathol, Div Med Microbiol, Baltimore, MD 21205 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2010年 / 120卷 / 09期

关键词：

MOUNTAIN-SPOTTED-FEVER; ANAPLASMA-PHAGOCYTOPHILUM; UNITED-STATES; GENE-EXPRESSION; HOST; MECHANISMS; DISEASES; EVASION; MODEL;

D O I：

10.1172/JCI44402

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Microbes transmitted to mammals by arthropods contend with many factors that could impede survival. To survive, host fitness with infection must outweigh costs. In this issue of the JCI, Neelakanta et al. demonstrate that ticks infected with Anaplasma phagocytophilum show enhanced fitness against freezing injury owing to induced expression of tick "antifreeze glycoprotein." This allows A. phagocytophilum to successfully propagate and survive to cause disease in nonnatural hosts, such as humans. How an intracellular microbe with a small genome subverts host cell function for survival provides insight into the control of some cellular function programs and underscores how vector biology can have an impact on human health.

引用

页码：3087 / 3090

页数：4

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