Synthesis of the C8-deoxyguanosine adduct of the food mutagen IQ

被引：62

作者：

Wang, ZW ^{[1
]}

Rizzo, CJ ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Chem, Nashville, TN 37235 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 04期

关键词：

D O I：

10.1021/ol006968h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The C8-2'-deoxyguanosine adduct of the food mutagen 2-amino-3-methylimadazo[4,5-f]-quinoline (IQ) has been synthesized, The key step is a palladium catalyzed N-arylation of a suitably protected 8-bromo-2'-deoxygunaosine derivative.

引用

页码：565 / 568

页数：4

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