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Dinucleosomes show compaction by ionic strength, consistent with bending of linker DNA

被引：32
作者：
Butler, PJG
Thomas, JO
机构：
[1] Cambridge Ctr Mol Recognit, Cambridge CB2 1GA, England
[2] Dept Biochem, Cambridge CB2 1GA, England
[3] MRC, Mol Biol Lab, Cambridge CB2 2QH, England
来源：
JOURNAL OF MOLECULAR BIOLOGY | 1998年 / 281卷 / 03期
基金：
英国生物技术与生命科学研究理事会;
关键词：
chromatin; dinucleosomes; linker DNA; sedimentation; DNA bending;
D O I：
10.1006/jmbi.1998.1954
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nucleosome dimers from chicken erythrocytes show an ionic strength dependence of sedimentation coefficient similar to that of trimers, and indicative of a degree of compaction over a range of low ionic strengths. This is not easily reconciled with straight linkers but is consistent with bending or kinking of the linker DNA. (C) 1998 Academic Press.
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页码：401 / 407
页数：7
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