Glypican-3 expression in benign liver tissue with active hepatitis C: implications for the diagnosis of hepatocellular carcinoma

被引:54
作者
Abdul-Al, Hala M. [1 ,2 ]
Makhlouf, Hala R. [1 ,2 ]
Wang, Guanghua [1 ,2 ]
Goodman, Zachary D. [1 ,2 ]
机构
[1] Armed Forces Inst Pathol, Div Hepat Pathol, Washington, DC 20306 USA
[2] Armed Forces Inst Pathol, Vet Adm Special Reference Lab Pathol, Washington, DC 20306 USA
关键词
glypican-3; Ki-67; hepatitis C; immunohistochemistry;
D O I
10.1016/j.humpath.2007.06.004
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Glypican 3 is an oncofetal antigen that shows great promise as an adjunct to the diagnosis of hepatocellular carcinoma. To investigate whether glypican 3 might also appear in nonneoplastic liver cells, we performed immunostains on 60 biopsies of chronic hepatitis C, 30 with low-grade activity and 30 with high-grade activity. Glypican 3 immunoreactivity was detected in 25 (83.6%) of 30 in the high-grade but in none in the low-grade group. In 20% of the positive cases, glypican 3 produced strong cytoplasmic staining of more than 25% of hepatocytes and could potentially lead to a misdiagnosis of hepatocellular carcinoma. Pathologists should be aware of this phenomenon and exercise caution in interpreting biopsies or other specimens of suspected hepatocellular carcinoma when active necroinflammatory disease is present. (C) 2008 Published by Elsevier Inc.
引用
收藏
页码:209 / 212
页数:4
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