The guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer

被引:90
作者
Fields, Alan P. [1 ]
Justilien, Verline [1 ]
机构
[1] Mayo Clin, Ctr Comprehens Canc, Dept Canc Biol, Jacksonville, FL 32224 USA
来源
ADVANCES IN ENZYME REGULATION, VOL 50 | 2010年 / 50卷
关键词
PROTEIN-KINASE-C; CYTOKINESIS REGULATOR ECT2; CELL TRANSFORMING SEQUENCE-2; CONTRACTILE RING; RHO-GTPASES; PKC-IOTA; LUNG; AMPLIFICATION; EXPRESSION; POLARITY;
D O I
10.1016/j.advenzreg.2009.10.010
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
070307 [化学生物学]; 071010 [生物化学与分子生物学];
摘要
[No abstract available]
引用
收藏
页码:190 / 200
页数:11
相关论文
共 58 条
[1]
Balsara BR, 1997, CANCER RES, V57, P2116
[2]
GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases [J].
Birkenfeld, Joerg ;
Nalbant, Perihan ;
Bohl, Benjamin P. ;
Pertz, Olivier ;
Hahn, Klaus M. ;
Bokoch, Gary M. .
DEVELOPMENTAL CELL, 2007, 12 (05) :699-712
[3]
A superfamily of conserved domains in DNA damage responsive cell cycle checkpoint proteins [J].
Bork, P ;
Hofmann, K ;
Bucher, P ;
Neuwald, AF ;
Altschul, SF ;
Koonin, EV .
FASEB JOURNAL, 1997, 11 (01) :68-76
[4]
DNA amplification on chromosome 3q26.1-q26.3 in squamous cell carcinoma of the lung detected by reverse chromosome painting [J].
Brass, N ;
Ukena, I ;
Remberger, K ;
Mack, U ;
Sybrecht, GW ;
Meese, EU .
EUROPEAN JOURNAL OF CANCER, 1996, 32A (07) :1205-1208
[5]
Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells [J].
Burkard, Mark E. ;
Randall, Catherine L. ;
Larochelle, Stephane ;
Zhang, Chao ;
Shokat, Kevan M. ;
Fisher, Robert P. ;
Jallepalli, Prasad V. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (11) :4383-4388
[6]
From BRCA1 to RAP1: A widespread BRCT module closely associated with DNA repair [J].
Callebaut, I ;
Mornon, JP .
FEBS LETTERS, 1997, 400 (01) :25-30
[7]
Amplification of the Ect2 proto-oncogene and over-expression of Ect2 mRNA and protein in nickel compound and methylcholanthrene-transformed 10T1/2 mouse fibroblast cell lines [J].
Clemens, F ;
Verma, R ;
Ramnath, J ;
Landolph, JR .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2005, 206 (02) :138-149
[8]
Centrosome separation and central spindle assembly act in redundant pathways that regulate microtubule density and trigger cleavage furrow formation [J].
Dechant, R ;
Glotzer, M .
DEVELOPMENTAL CELL, 2003, 4 (03) :333-344
[9]
Rho GTPase expression in tumourigenesis:: evidence for a significant link [J].
del Pulgar, TG ;
Benitah, SA ;
Valerón, PF ;
Espina, C ;
Lacal, JC .
BIOESSAYS, 2005, 27 (06) :602-613
[10]
Atypical PKCι contributes to poor prognosis through loss of apical-basal polarity and Cyclin E overexpression in ovarian cancer [J].
Eder, AM ;
Sui, XM ;
Rosen, DG ;
Nolden, LK ;
Cheng, KW ;
Lahad, JP ;
Kango-Singh, M ;
Lu, KH ;
Warneke, CL ;
Atkinson, EN ;
Bedrosian, I ;
Keyomarsi, K ;
Kuo, WL ;
Gray, JW ;
Yin, JCP ;
Liu, JS ;
Halder, G ;
Mills, GB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (35) :12519-12524