Wnt signaling in the intestinal epithelium: from endoderm to cancer

被引：519

作者：

Gregorieff, A ^{[1
]}

Clevers, H ^{[1
]}

机构：

[1] Netherlands Inst Dev Biol, Hubrecht Lab, NL-3584 CT Utrecht, Netherlands

来源：

GENES & DEVELOPMENT | 2005年 / 19卷 / 08期

关键词：

WNT; cancer; intestine;

D O I：

10.1101/gad.1295405

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Wnt pathway controls cell fate during embryonic development. It also persists as a key regulator of homeostasis in adult self-renewing tissues. In these tissues, mutational deregulation of the Wnt cascade is closely associated with malignant transformation. The intestinal epithelium represents the best-understood example for the closely linked roles of Wnt signaling in homeostatic self-renewal and malignant transformation. in this review, we outline current understanding of the physiological role of Wnt signaling in intestinal biology. From this perspective, we then describe how mutational subversion of the Wnt cascade leads to colorectal cancer.

引用

页码：877 / 890

页数：14

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