Microwave-assisted direct amination:: Rapid access to multi-functionalized N6-substituted adenosines

被引：14

作者：

Ashton, Trent D. ^{[1
]}

Scammells, Peter J. ^{[1
]}

机构：

[1] Monash Univ, Victorian Coll Pharm, Dept Med Chem, Parkville, Vic 3052, Australia

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 2008年 / 61卷 / 01期

关键词：

D O I：

10.1071/CH07340

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Analogues of adenosine have a range of interesting biological activities and potential therapeutic applications. A method for the efficient preparation of highly functionalized N-6-substituted adenosines has been developed from the corresponding tert-butyldimethylsilyl-protected inosine. The key step in this procedure is a microwave-assisted amination reaction between an appropriately substituted inosine and an amine in the presence of PyBroP. High yields of desired N6-substituted adenosines were achieved with hindered amines and the reaction was also found to accommodate a range of substituents on the inosine precursor.

引用

页码：49 / 58

页数：10

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