Decoding the secrets of spider silk

被引:259
作者
Eisoldt, Lukas [1 ]
Smith, Andrew [1 ]
Scheibel, Thomas [1 ]
机构
[1] Univ Bayreuth, Fak Angew Nat Wissensch, Lehrstuhl Biomat, D-95447 Bayreuth, Germany
关键词
CLAVIPES DRAGLINE SILK; MAJOR AMPULLATE SILK; FIBROIN GENE FAMILY; MECHANICAL-PROPERTIES; ESCHERICHIA-COLI; NEPHILA-EDULIS; C-13; NMR; IN-VIVO; PROTEINS; FIBERS;
D O I
10.1016/S1369-7021(11)70057-8
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Spider silks have been employed by man for several thousands of years. Spider silks possess extraordinary mechanical properties due to a combination of strength and extensibility that are superior to most man-made fibers. Spider silk fibers are a protein-based material produced in a highly sophisticated hierarchical process under mild conditions. Here, we review the current understanding of spider silk and its assembly process, as well as discuss the application of silk-based materials to the fields of biomedicine and materials engineering.
引用
收藏
页码:80 / 86
页数:7
相关论文
共 97 条
[1]   Three-dimensional scaffold made from recombinant spider silk protein for tissue engineering [J].
Agapov, I. I. ;
Pustovalova, O. L. ;
Moisenovich, M. M. ;
Bogush, V. G. ;
Sokolova, O. S. ;
Sevastyanov, V. I. ;
Debabov, V. G. ;
Kirpichnikov, M. P. .
DOKLADY BIOCHEMISTRY AND BIOPHYSICS, 2009, 426 (01) :127-130
[2]   Bioprospecting Finds the Toughest Biological Material: Extraordinary Silk from a Giant Riverine Orb Spider [J].
Agnarsson, Ingi ;
Kuntner, Matjaz ;
Blackledge, Todd A. .
PLOS ONE, 2010, 5 (09) :1-8
[3]   Spider silk fibres in artificial nerve constructs promote peripheral nerve regeneration [J].
Allmeling, C. ;
Jokuszies, A. ;
Reimers, K. ;
Kall, S. ;
Choi, C. Y. ;
Brandes, G. ;
Kasper, C. ;
Scheper, T. ;
Guggenheim, M. ;
Vogt, P. M. .
CELL PROLIFERATION, 2008, 41 (03) :408-420
[4]   Use of spider silk fibres as an innovative material in a biocompatible artificial nerve conduit [J].
Allmeling, Christina ;
Jokuszies, Andreas ;
Reimers, Kerstin ;
Kall, Susanne ;
Vogt, Peter M. .
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2006, 10 (03) :770-777
[5]   AMINO ACID COMPOSITION OF SPIDER SILDS [J].
ANDERSEN, SO .
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY, 1970, 35 (03) :705-&
[6]   Purification and characterization of recombinant spider silk expressed in Escherichia coli [J].
Arcidiacono, S ;
Mello, C ;
Kaplan, D ;
Cheley, S ;
Bayley, H .
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 1998, 49 (01) :31-38
[7]   Self-assembly of spider silk proteins is controlled by a pH-sensitive relay [J].
Askarieh, Glareh ;
Hedhammar, My ;
Nordling, Kerstin ;
Saenz, Alejandra ;
Casals, Cristina ;
Rising, Anna ;
Johansson, Jan ;
Knight, Stefan D. .
NATURE, 2010, 465 (7295) :236-U125
[8]  
Augsten K, 2000, SCANNING, V22, P12
[9]   Blueprint for a High-Performance Biomaterial: Full-Length Spider Dragline Silk Genes [J].
Ayoub, Nadia A. ;
Garb, Jessica E. ;
Tinghitella, Robin M. ;
Collin, Matthew A. ;
Hayashi, Cheryl Y. .
PLOS ONE, 2007, 2 (06)
[10]   Silken toolkits:: biomechanics of silk fibers spun by the orb web spider Argiope argentata (Fabricius 1775) [J].
Blackledge, TA ;
Hayashi, CY .
JOURNAL OF EXPERIMENTAL BIOLOGY, 2006, 209 (13) :2452-2461