Age- and gender-related differences in maximum shortening velocity of skeletal muscle fibers

被引:114
作者
Krivickas, LS
Suh, DW
Wilkins, J
Hughes, VA
Roubenoff, R
Frontera, WR
机构
[1] Spaulding Rehabil Hosp, Dept Phys Med & Rehabil, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Nutr Exercise Physiol & Sarcopenia Lab, Boston, MA USA
关键词
single muscle fiber; shortening velocity; aging; muscle power;
D O I
10.1097/00002060-200106000-00012
中图分类号
R49 [康复医学];
学科分类号
100215 ;
摘要
Objective: To determine age- and gender-related differences in maximum unloaded shortening velocity (Vo) of Type I and IIA single muscle fibers. Muscle fibers must have a broad range of contractile velocities to generate the full range of power required for varied activities. Design: Percutaneous needle biopsies of the vastus lateralis were obtained from 31 healthy subjects (n = 7 young men [YM], n = 7 young women [YW], n = 12 older men [OM], n = 12 older women [OW]). The slack test was used to determine Vo of individual fibers; 916 muscle fibers were chemically skinned. Fiber type was determined by myosin heavy chain isoform identification. Results: Among men, Vo (fiber lengths/sec) was reduced with age in Type IIA fibers (OM vs. YM: 1.78 vs. 2.14; P < 0.05) but unchanged in Type I fibers. Among women, Vo was reduced with age in Type I fibers (OW vs. YW: 0.70 vs. 0.75; P < 0.05) but not IIA. OW had a lower Vo than did OM in both fiber types (Type I: OW = 0.70, OM = 0.77; Type IIA: OW = 1.51, OM = 1.78; P < 0.05). YW did not differ from YM. Conclusions: Both age and gender affect Vo. Age- and gender-related differences in Vo may partially explain the impairments in muscle function that occur with aging and the greater impairment in muscle function observed in OW compared with that observed in OM.
引用
收藏
页码:447 / 455
页数:9
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