DNA-templated self-assembly of protein and nanoparticle linear arrays

被引:277
作者
Li, HY [1 ]
Park, SH [1 ]
Reif, JH [1 ]
LaBean, TH [1 ]
Yan, H [1 ]
机构
[1] Duke Univ, Dept Comp Sci, Durham, NC 27708 USA
关键词
D O I
10.1021/ja0383367
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Self-assembling DNA tiling lattices represent a versatile system for nanoscale construction. Self-assembled DNA arrays provide an excellent template for spatially positioning other molecules with increased relative precision and programmability. Here we report an experiment using a linear array of DNA triple crossover tiles to controllably template the self-assembly of single-layer or double-layer linear arrays of streptavidin molecules and streptavidin-conjugated nanogold particles through biotin-streptavidin interaction. The organization of streptavidin and its conjugated gold nanoparticles into periodic arrays was visualized by atomic force microscopy and scanning electron microscopy. Copyright © 2004 American Chemical Society.
引用
收藏
页码:418 / 419
页数:2
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