Transition metal-catalyzed intermolecular [5+2] and [5+2+1] cycloadditions of allenes and vinylcyclopropanes

被引:140
作者
Wegner, HA
de Meijere, A
Wender, PA [1 ]
机构
[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA
[2] Stanford Univ, Dept Mol Pharmacol, Stanford, CA 94305 USA
[3] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany
关键词
D O I
10.1021/ja043671w
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Initial examples of the intermolecular Rh(I)-catalyzed [5+2] cycloaddition reaction of bifunctional allenes and vinylcyclopropanes are described. The reactions proceed with facility and in yields of up to 99% with a variety of alkyne-, ester-, styrene-, or cyano-substituents on the allene to afford the corresponding cycloadducts. In the presence of CO, the reaction proceeds to an eight-membered ring cycloadduct and its transannularly closed product, providing the first example of a three-component [5+2+1] cycloaddition with allenes. Copyright © 2005 American Chemical Society.
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页码:6530 / 6531
页数:2
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