Genetic epidemiology - Approaches to the genetic analysis of rheumatoid arthritis

被引：13

作者：

John, S

Worthington, J

机构：

[1] Univ Manchester, ARC Epidemiol Unit, Manchester M13 9PT, Lancs, England

[2] AstraZeneca, Macclesfield, Cheshire, England

来源：

ARTHRITIS RESEARCH | 2001年 / 3卷 / 04期

关键词：

genetic analysis; rheumatoid arthritis;

D O I：

10.1186/ar304

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The basis of susceptibility to rheumatoid arthritis (RA) is complex, comprising genetic and environmental susceptibility factors. We have reviewed the available approaches to the investigation of the genetic basis of complex diseases and how these are being applied to RA. Affected-sibling-pair methods for nonparametric linkage analysis, linkage-disequilibrium-based approaches, transmission disequilibrium testing, and disease-association studies are discussed. The pros, cons, and limitations of the approaches are considered and are illustrated by examples from the literature about rheumatoid arthritis.

引用

页码：216 / 220

页数：5

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