Homeodomain interactions

被引：121

作者：

Wolberger, C

机构：

[1] Dept. Biophys. and Biophysical Chem., John Hopkins School of Medicine, Baltimore, MD 21205

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1996年 / 6卷 / 01期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0959-440X(96)80096-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Homeodomain proteins play key roles in development and gene regulation in eukaryotes. Past structural studies have focused on the binding of monomeric homeodomains to DNA, but two recent structures have revealed how homeodomains bind DNA as multimers. The structures of the Drosophila Paired homodimer and the yeast alpha 1/alpha 2 heterodimer bound to DNA, along with a high-resolution study of a Drosophila eve-DNA complex, have deepened our understanding of how homeodomains locate their DNA targets.

引用

收藏

页码：62 / 68

页数：7

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