Quinine and chloroquine differentially perturb heme monomer-dimer equilibrium

被引：37

作者：

Casabianca, Leah B. ^{[1
]}

An, David ^{[1
]}

Natarajan, Jayakumar K. ^{[1
,2
]}

Alumasa, John N. ^{[1
]}

Roepe, Paul D. ^{[1
,2
,3
]}

Wolf, Christian ^{[1
,3
]}

de Dios, Angel C. ^{[1
,3
]}

机构：

[1] Georgetown Univ, Dept Chem, Washington, DC 20057 USA

[2] Georgetown Univ, Dept Biochem & Cellular & Mol Biol, Washington, DC 20057 USA

[3] Georgetown Univ, Ctr Infect Dis, Washington, DC 20057 USA

来源：

INORGANIC CHEMISTRY | 2008年 / 47卷 / 13期

关键词：

D O I：

10.1021/ic800440d

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Nuclear magnetic resonance (NMR) measurements of magnetic susceptibility have been utilized to study the equilibrium between two forms (high-spin monomer vs the antiferromagnetically coupled mu-oxo dimer) of ferriprotoporphyrin(IX) as a function of pH. The pH dependence of this equilibrium is significantly altered by the addition of either chloroquine or quinine. Chloroquine promotes the mu-oxo dimer whereas quinine promotes the monomer.

引用

页码：6077 / 6081

页数：5

共 15 条

[1] Drug resistance-associated pfCRT mutations confer decreased Plasmodium falciparum digestive vacuolar pH [J].

Bennett, TN ;

Kosar, AD ;

Ursos, LMB ;

Dzekunov, S ;

Sidhu, ABS ;

Fidock, DA ;

Roepe, PD .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2004, 133 (01) :99-114

[2] H-1-NMR STUDY OF HIGH-SPIN FERRIC NATURAL PORPHYRIN DERIVATIVES AS MODELS OF METHEMOPROTEINS [J].

BUDD, DL ;

LAMAR, GN ;

LANGRY, KC ;

SMITH, KM ;

NAYYIRMAZHIR, R .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1979, 101 (20) :6091-6096

[3] PICKET-FENCE PORPHYRINS - SYNTHETIC MODELS FOR OXYGEN BINDING HEMOPROTEINS [J].

COLLMAN, JP ;

GAGNE, RR ;

REED, CA ;

HALBERT, TR ;

LANG, G ;

ROBINSON, WT .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1975, 97 (06) :1427-1439

[4] Speciation and structure of ferriprotoporphyrin IX in aqueous solution:: spectroscopic and diffusion measurements demonstrate dimerization, but not μ-oxo dimer formation [J].

de Villiers, Katherine A. ;

Kaschula, Catherine H. ;

Egan, Timothy J. ;

Marques, Helder M. .

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2007, 12 (01) :101-117

[5] THE DETERMINATION OF THE PARAMAGNETIC SUSCEPTIBILITY OF SUBSTANCES IN SOLUTION BY NUCLEAR MAGNETIC RESONANCE [J].

EVANS, DF .

JOURNAL OF THE CHEMICAL SOCIETY, 1959, (JUN) :2003-2005

[6] THERMODYNAMIC AND KINETIC PROPERTIES OF AN IRON-PORPHYRIN SYSTEM [J].

FLEISCHER, EB ;

PALMER, JM ;

SRIVASTAVA, TS ;

CHATTERJEE, A .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1971, 93 (13) :3162-+

[7] Spectroscopic study of a water-soluble iron(III) meso-tetrakis(4-N-methylpyridiniumyl) porphyrin in aqueous solution:: effects of pH and salt [J].

Gandini, SCM ;

Vidoto, EA ;

Nascimento, OR ;

Tabak, M .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2003, 94 (1-2) :127-137

[8] Spinning disk confocal microscopy of live, intraerythrocytic malarial parasites. 2. Altered vacuolar volume regulation in drug resistant malaria [J].

Gligorijevic, Bojana ;

Bennett, Tyler ;

McAllister, Ryan ;

Urbach, Jeffrey S. ;

Roepe, Paul D. .

BIOCHEMISTRY, 2006, 45 (41) :12411-12423

[9] PROTON MAGNETIC-RESONANCE INVESTIGATION OF ANTIFERROMAGNETIC OXO-BRIDGED FERRIC DIMERS AND RELATED HIGH-SPIN MONOMERIC FERRIC COMPLEXES [J].

LAMAR, GN ;

EATON, GR ;

HOLM, RH ;

WALKER, FA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1973, 95 (01) :63-75

[10] Solution structures of antimalarial drug-heme complexes [J].

Leed, A ;

DuBay, K ;

Ursos, LMB ;

Sears, D ;

de Dios, AC ;

Roepe, PD .

BIOCHEMISTRY, 2002, 41 (32) :10245-10255

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