SMALL RANDOMIZED TRIAL AMONG LOW-BIRTH-WEIGHT CHILDREN RECEIVING BACILLUS CALMETTE-GUERIN VACCINATION AT FIRST HEALTH CENTER CONTACT

被引：205

作者：

Biering-Sorensen, Sofie ^{[1
,2
]}

Aaby, Peter ^{[1
,2
]}

Napirna, Bitiguida Mutna ^{[3
]}

Roth, Adam ^{[1
,4
]}

Ravn, Henrik ^{[1
]}

Rodrigues, Amabelia ^{[2
]}

Whittle, Hilton ^{[5
]}

Benn, Christine Stabell ^{[1
,2
]}

机构：

[1] Statens Serum Inst, Bandim Hlth Project, DK-2300 Copenhagen S, Denmark

[2] Indepth Network, Bandim Hlth Project, Bissau, Guinea Bissau

[3] Hosp Nacl Simao Mendes, Bissau, Guinea Bissau

[4] Lund Univ, Dept Med Microbiol, Malmo, Sweden

[5] MRC Labs, Fajara, Gambia

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2012年 / 31卷 / 03期

基金：

欧洲研究理事会; 新加坡国家研究基金会;

关键词：

BCG; infant mortality; neonatal mortality; nonspecific effects of vaccines;

D O I：

10.1097/INF.0b013e3182458289

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A total of 105 low-birth-weight children presenting for first vaccination were randomized to receive bacillus Calmette-Guerin (BCG) immediately or later (current practice). The mortality rate ratio for BCG was 0.17 (95% CI = 0.02-1.35) within 3 days of enrollment, 0.28 (0.06-1.37) in the first month, and 0.27 (0.07-0.98) after 2 months of age. The mortality rate ratio was 0.41 (0.14-1.18) (P = 0.098) in infancy. Administration of BCG vaccine at first contact may contribute to lower mortality.

引用

页码：306 / 308

页数：3

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