Seroprevalence of antibodies against SARS-CoV-2 among health care workers in a large Spanish reference hospital

被引：251

作者：

Garcia-Basteiro, Alberto L. ^{[1
,2
,3
]}

Moncunill, Gemma ^{[1
]}

Tortajada, Marta ^{[4
]}

Vidal, Marta ^{[1
]}

Guinovart, Caterina ^{[1
]}

Jimenez, Alfons ^{[1
,5
]}

Santano, Rebeca ^{[1
]}

Sanz, Sergi ^{[1
,5
,6
]}

Mendez, Susana ^{[1
,5
]}

Llupia, Anna ^{[1
,7
]}

Aguilar, Ruth ^{[1
]}

Alonso, Selena ^{[1
]}

Barrios, Diana ^{[1
]}

Carolis, Carlo ^{[8
]}

Cistero, Pau ^{[1
]}

Choliz, Eugenia ^{[9
]}

Cruz, Angeline ^{[1
]}

Fochs, Silvia ^{[1
]}

Jairoce, Chenjerai ^{[1
,3
]}

Hecht, Jochen ^{[8
]}

Lamoglia, Montserrat ^{[1
,10
]}

Martinez, Mikel J. ^{[1
,11
]}

Mitchell, Robert A. ^{[1
]}

Ortega, Natalia ^{[1
]}

Pey, Nuria ^{[1
]}

Puyol, Laura ^{[1
]}

Ribes, Marta ^{[1
]}

Rosell, Neus ^{[1
]}

Sotomayor, Patricia ^{[1
]}

Torres, Sara ^{[1
]}

Williams, Sarah ^{[1
]}

Barroso, Sonia ^{[4
]}

Vilella, Anna ^{[1
,7
]}

Munoz, Jose ^{[1
,2
]}

Trilla, Antoni ^{[1
,7
,9
]}

Varela, Pilar ^{[4
]}

Mayor, Alfredo ^{[1
,3
,5
]}

Dobano, Carlota ^{[1
,5
]}

机构：

[1] Univ Barcelona, ISGlobal, Hosp Clin, Barcelona, Spain

[2] Univ Barcelona, Hosp Clin, Int Hlth Dept, Barcelona, Spain

[3] Ctr Invest Saude Manh CISM, Maputo, Mozambique

[4] Univ Barcelona, Hosp Clin, Occupat Hlth Dept, Barcelona, Spain

[5] Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Madrid, Spain

[6] Univ Barcelona, Fac Med, Dept Basic Clin Practice, Barcelona, Spain

[7] Univ Barcelona, Hosp Clin, Dept Prevent Med & Epidemiol, Barcelona, Spain

[8] Barcelona Inst Sci & Technol, Ctr Genom Regulat CRG, Barcelona, Spain

[9] Univ Barcelona, Fac Med & Hlth Sci, Barcelona, Spain

[10] Univ Ramon Llull Barcelona, Fac Hlth Sci Blanquerna, Barcelona, Spain

[11] Univ Barcelona, Hosp Clin, Dept Microbiol, Barcelona, Spain

来源：

NATURE COMMUNICATIONS | 2020年 / 11卷 / 01期

关键词：

CORONAVIRUS INFECTION; IMMUNE-RESPONSE; COVID-19;

D O I：

10.1038/s41467-020-17318-x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Health care workers (HCW) are a high-risk population to acquire SARS-CoV-2 infection from patients or other fellow HCW. This study aims at estimating the seroprevalence against SARS-CoV-2 in a random sample of HCW from a large hospital in Spain. Of the 578 participants recruited from 28 March to 9 April 2020, 54 (9.3%, 95% CI: 7.1-12.0) were seropositive for IgM and/or IgG and/or IgA against SARS-CoV-2. The cumulative prevalence of SARS-CoV-2 infection (presence of antibodies or past or current positive rRT-PCR) was 11.2% (65/578, 95% CI: 8.8-14.1). Among those with evidence of past or current infection, 40.0% (26/65) had not been previously diagnosed with COVID-19. Here we report a relatively low seroprevalence of antibodies among HCW at the peak of the COVID-19 epidemic in Spain. A large proportion of HCW with past or present infection had not been previously diagnosed with COVID-19, which calls for active periodic rRT-PCR testing in hospital settings. Health care workers (HCW) are a high-risk population for SARS-CoV-2 infection. Here, the authors determine seroprevalence against SARS-CoV-2 in HCWs of a large Spanish reference hospital and find a cumulative prevalence of SARS-CoV-2 infection (presence of antibodies or past or current positive rRT-PCR) of 11%.

引用

页数：9

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