Immunopathogenesis of multiple sclerosis

被引：100

作者：

Comabella, Manuel ^{[1
]}

Khoury, Samia J. ^{[2
]}

机构：

[1] HUVH, CEM Cat, Ctr Esclerosi Multiple Catalunya, Unitat Neuroimmunol Clin, Barcelona, Spain

[2] Harvard Univ, Sch Med, Partners MS Ctr, Boston, MA USA

来源：

CLINICAL IMMUNOLOGY | 2012年 / 142卷 / 01期

关键词：

Multiple sclerosis; Pathogenesis; Cellular immunity; Immunotherapy; CENTRAL-NERVOUS-SYSTEM; MYELIN BASIC-PROTEIN; CD8(+) T-CELLS; CEREBROSPINAL-FLUID; AUTOIMMUNE ENCEPHALOMYELITIS; CLONAL EXPANSIONS; MEDICAL PROGRESS; AXONAL INJURY; T(H)17 CELLS; LYMPHOCYTES;

D O I：

10.1016/j.clim.2011.03.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Multiple sclerosis (MS) is a chronic disorder of the central nervous system characterized by autoimmune inflammation, demyelination, and axonal damage. MS etiology remains unknown, but disease phenotype is most likely the result of an interaction between complex genetic factors and environmental influences. The better understanding of the mechanisms involved in the immunopathogenesis of MS has led to the development of promising new therapeutic strategies for the disease. This review will discuss the key pathogenic steps implicated in the disease and the role of the main cellular populations that drive the immune responses in MS. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：2 / 8

页数：7

共 49 条

[1]

Clonal expansions of CD8+ T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction [J].

Babbe, H ;

Roers, A ;

Waisman, A ;

Lassmann, H ;

Goebels, N ;

Hohlfeld, R ;

Friese, M ;

Schröder, R ;

Deckert, M ;

Schmidt, S ;

Ravid, R ;

Rajewsky, K .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (03) :393-404

[2]

Acute axonal injury in multiple sclerosis -: Correlation with demyelination and inflammation [J].

Bitsch, A ;

Schuchardt, J ;

Bunkowski, S ;

Kuhlmann, T ;

Brück, W .

BRAIN, 2000, 123 :1174-1183

[3]

Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis [J].

Brucklacher-Waldert, Verena ;

Sturner, Klarissa ;

Kolster, Manuela ;

Wolthausen, Julia ;

Tolosa, Eva .

BRAIN, 2009, 132 :3329-3341

[4]

ISOLATION OF MYELIN BASIC PROTEIN-REACTIVE T-CELL LINES FROM NORMAL HUMAN-BLOOD [J].

BURNS, J ;

ROSENZWEIG, A ;

ZWEIMAN, B ;

LISAK, RP .

CELLULAR IMMUNOLOGY, 1983, 81 (02) :435-440

[5]

Multiple sclerosis [J].

Compston, Alastair ;

Coles, Alasdair .

LANCET, 2008, 372 (9648) :1502-1517

[6]

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci [J].

De Jager, Philip L. ;

Jia, Xiaoming ;

Wang, Joanne ;

de Bakker, Paul I. W. ;

Ottoboni, Linda ;

Aggarwal, Neelum T. ;

Piccio, Laura ;

Raychaudhuri, Soumya ;

Tran, Dong ;

Aubin, Cristin ;

Briskin, Rebeccah ;

Romano, Susan ;

Baranzini, Sergio E. ;

McCauley, Jacob L. ;

Pericak-Vance, Margaret A. ;

Haines, Jonathan L. ;

Gibson, Rachel A. ;

Naeglin, Yvonne ;

Uitdehaag, Bernard ;

Matthews, Paul M. ;

Kappos, Ludwig ;

Polman, Chris ;

McArdle, Wendy L. ;

Strachan, David P. ;

Evans, Denis ;

Cross, Anne H. ;

Daly, Mark J. ;

Compston, Alastair ;

Sawcer, Stephen J. ;

Weiner, Howard L. ;

Hauser, Stephen L. ;

Hafler, David A. ;

Oksenberg, Jorge R. .

NATURE GENETICS, 2009, 41 (07) :776-U26

[7]

Medical progress: Multiple sclerosis - The plaque and its pathogenesis [J].

Frohman, EM ;

Racke, MK ;

Raine, CS .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (09) :942-955

[8]

Characterizing the mechanisms of progression in multiple sclerosis - Evidence and new hypotheses for future directions [J].

Frohman, EM ;

Filippi, M ;

Stuve, O ;

Waxman, SG ;

Corboy, J ;

Phillips, JT ;

Lucchinetti, C ;

Wilken, J ;

Karandikar, N ;

Hemmer, B ;

Monson, N ;

De Keyser, J ;

Hartung, H ;

Steinman, L ;

Oksenberg, JR ;

Cree, BAC ;

Hauser, S ;

Racke, MK .

ARCHIVES OF NEUROLOGY, 2005, 62 (09) :1345-1356

[9]

Swift entry of myelin-specific T lymphocytes into the central nervous system in spontaneous autoimmune encephalomyelitis [J].

Furtado, Glaucia C. ;

Marcondes, Maria Cecilia G. ;

Latkowski, Jo-Ann ;

Tsai, Julia ;

Wensky, Allen ;

Lafaille, Juan J. .

JOURNAL OF IMMUNOLOGY, 2008, 181 (07) :4648-4655

[10]

T-bet regulates the fate of Th1 and Th17 lymphocytes in autoimmunity [J].

Gocke, Anne R. ;

Cravens, Petra D. ;

Ben, Li-Hong ;

Hussain, Rehana Z. ;

Northrop, Sara C. ;

Racke, Michael K. ;

Lovett-Racke, Amy E. .

JOURNAL OF IMMUNOLOGY, 2007, 178 (03) :1341-1348

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