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Cancer research 2001: drug resistance, new targets and drug combinations

被引：15
作者：
Broxterman, HJ
Georgopapadakou, N
机构：
[1] Vrije Univ Amsterdam, Dept Med Oncol, Amsterdam, Netherlands
[2] NewBiot, San Diego, CA USA
来源：
DRUG RESISTANCE UPDATES | 2001年 / 4卷 / 03期
关键词：
D O I：
10.1054/drup.2001.0216
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The development of new anticancer drugs and the identification of novel targets represent major focus areas for pharmaceutical and biotech companies, universities and research institutes worldwide. The 92nd Annual Meeting of the American Association for Cancer Research (AACR) provided a glimpse of the latest developments in the cancer field. We highlight here presentations on resistance mechanisms (efflux, target modulation), new targets and drugs in development (topoisomerase, angiogenesis, cell cycle inhibitors) and new molecular technologies. The emergence of technologies for concurrently screening for expression of thousands of genes, has provided a new approach for the identification of molecular targets and mechanisms of both action and resistance of new compounds. The importance of inhibiting multiple targets simultaneously was brought up in several presentations. (C) 2001 Harcourt Publishers Ltd.
引用
收藏
页码：197 / 209
页数：13
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