Early BCR events and antigen captutre, processing, and loading on MHC class II on B cells

被引：77

作者：

Avelos, Ana M. ^{[1
]}

Ploegh, Hidde L. ^{[1
]}

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2014年 / 5卷

关键词：

B cell receptor; antigen valency; antigen recognition by BCR; antigen presentation by B cells; B cells as APC; SUBCAPSULAR SINUS; LYMPH-NODE; HLA-DO; RECEPTOR; COMPARTMENTS; LYMPHOCYTES; ACTIVATION; MONOVALENT; MICE; UBIQUITINATION;

D O I：

10.3389/fimmu.2014.00092

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

B cells are efficient antigen-presenting cells (APCs), relying on antigen uptake through the B cell receptor (BCR). The mechanism of antigen recognition remains a topic of debate; while the prevalent view holds that antigens need to be multivalent for BCR activation, monovalent antigens can also initiate B cell responses. In this review, we describe the steps required for antigen uptake, processing, and loading of peptides onto MHC Class II compartments in B cells for efficient presentation to CD4 T cells, with a special focus in the initial steps of BCR recognition of antigen.

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页数：5

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