Vanishing bile duct syndrome in human immunodeficiency virus: Nevirapine hepatotoxicity revisited

被引：12

作者：

Kochar, Rajan ^{[1
]}

Nevah, Moises I. ^{[1
]}

Lukens, Frank J. ^{[1
]}

Fallon, Michael B. ^{[1
]}

Machicao, Victor I. ^{[1
]}

机构：

[1] Univ Texas Hlth Sci Ctr Houston, Div Gastroenterol Hepatol & Nutr, Houston, TX 77030 USA

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2010年 / 16卷 / 26期

关键词：

Vanishing bile duct syndrome; Ductopenia; Acquired immune deficiency syndrome; Cholangiopathy; Cholestasis; Drug-induced liver injury; CHOLESTASIS; PATIENT;

D O I：

10.3748/wjg.v16.i26.3335

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Vanishing bile duct syndrome (VBDS) refers to a group of disorders characterized by prolonged cholestasis as a result of destruction and disappearance of intrahepatic bile ducts. Multiple etiologies have been indentified including infections, neoplastic disorders, autoimmune conditions and drugs. The natural history of this condition is variable and may involve resolution of cholestasis or progression with irreversible damage. VBDS is extremely rare in human immunodeficiency virus (HIV)-infected patients and anti-retroviral therapy has never been implicated as a cause. We encountered a young pregnant female with HIV and VBDS secondary to anti-retroviral therapy. Here, we report her clinical course and outcome. (C) 2010 Baishideng. All rights reserved.

引用

页码：3335 / 3338

页数：4

共 17 条

[1]

Vanishing bile duct syndrome in a patient with advanced AIDS.: HIV Med 2007; 8: 70-72 [J].

Aldeen, T. ;

Davies, S. .

HIV MEDICINE, 2007, 8 (08) :573-574

[2]

Hodgkin lymphoma-related vanishing bile duct syndrome and idiopathic cholestasis: Statistical analysis of all published cases and literature review [J].

Ballonoff, Ari ;

Kavanagh, Brian ;

Nash, Russell ;

Drabkin, Harry ;

Trotter, James ;

Costa, Luciano ;

Rabinovitch, Rachel .

ACTA ONCOLOGICA, 2008, 47 (05) :962-970

[3]

Chlumska A, 2001, Cesk Patol, V37, P118

[4]

Late onset hepatitis and prolonged deterioration in hepatic function associated with nevirapine therapy [J].

Clarke, S ;

Harrington, P ;

Condon, C ;

Kelleher, D ;

Smith, OP ;

Mulcahy, F .

INTERNATIONAL JOURNAL OF STD & AIDS, 2000, 11 (05) :336-337

[5]

Intrahepatic cholestasis of pregnancy [J].

Geenes, Victoria ;

Williamson, Catherine .

WORLD JOURNAL OF GASTROENTEROLOGY, 2009, 15 (17) :2049-2066

[6]

Vanishing bile duct syndrome in a patient with advanced AIDS [J].

Hindupur, S. ;

Yeung, M. ;

Shroff, P. ;

Fritz, J. ;

Kirmani, N. .

HIV MEDICINE, 2007, 8 (01) :70-72

[7]

Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis [J].

Kita, H ;

Matsumura, S ;

He, XS ;

Ansari, AA ;

Lian, ZX ;

Van de Water, J ;

Coppel, RL ;

Kaplan, MM ;

Gershwin, ME .

JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (09) :1231-1240

[8]

SMALL-DUCT PRIMARY SCLEROSING CHOLANGITIS [J].

LUDWIG, J .

SEMINARS IN LIVER DISEASE, 1991, 11 (01) :11-17

[9]

IDIOPATHIC ADULTHOOD DUCTOPENIA - A CAUSE OF CHRONIC CHOLESTATIC LIVER-DISEASE AND BILIARY-CIRRHOSIS [J].

LUDWIG, J ;

WIESNER, RH ;

LARUSSO, NF .

JOURNAL OF HEPATOLOGY, 1988, 7 (02) :193-199

[10]

Medrano J, 2008, AIDS REV, V10, P110

← 1 2 →