Biotransformation of 3-Oxo-Oleanolic Acid by Absidia glauca

被引：16

作者：

Guo, Na ^{[1
,2
,3
]}

Zhao, Ying ^{[1
,2
,3
]}

Fang, Wei-Shuo ^{[1
,2
,3
]}

机构：

[1] Peking Union Med Coll, Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, Beijing 100050, Peoples R China

[2] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

[3] Minist Hlth, Key Lab Biosynth Nat Prod, Beijing, Peoples R China

来源：

PLANTA MEDICA | 2010年 / 76卷 / 16期

关键词：

Absidia glauca Hagem; hydroxylation; triterpenoids; beta-cyclodextrin; anticancer; OLEANOLIC ACID; MICROBIAL TRANSFORMATION; TRITERPENES;

D O I：

10.1055/s-0030-1250047

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

3-Oxo-oleanolic acid (1) was biotransformed in growing cultures of the fungus Absidia glauca, resulting in three novel hydroxylated metabolites, identified as 1 beta-hydroxy-3-oxo-olean-11-en- 28,13-lactone (2), 1 beta,11 alpha-dihydroxy-3-oxo-olean-12-en-28-oic acid (3), and 1 beta,11 alpha,21 beta-trihydroxy-3-oxo-olean-12-en-28-oic acid (4).

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页码：1904 / 1907

页数：4

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