A standard immunoglobulin preparation produced from bovine colostra shows antibody reactivity and neutralization activity against Shiga-like toxins and EHEC-hemolysin of Escherichia coli O157:H7

被引：34

作者：

Lissner, R

Schmidt, H

Karch, H

机构：

[1] UNIV WURZBURG, INST HYG & MICKROBIOL, D-97080 WURZBURG, GERMANY

[2] BIOTEST PHARMA GMBH, D-63303 DREIEICH, GERMANY

来源：

INFECTION | 1996年 / 24卷 / 05期

关键词：

D O I：

10.1007/BF01716084

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Enterohemorrhagic Escherichia coli (EHEC) causes a variety of clinical conditions, the most important being hemorrhagic colitis and hemolytic uremic syndrome, A curative therapy of EHEC diseases is not yet feasible. This study investigates the antibody reactivity of Lactobin(R), a standardized immunoglobulin (Ig) preparation, obtained from the colostra of non-immunized cows, Three different batches of Lactobin(R) exhibited equally high titers of specific antibodies against Shiga-like toxins (SLTs, verocytotoxins) and EHEC hemolysin (EHEC-Hly) produced by E. coli O157. In addition, Lactobin(R) blocked the cytotoxic effect of SLT-I and SLT-II on Vero cell monolayers and inhibited the cytolytic effects of EHEC-Hly on human erythrocytes. Since Lactobin(R) contains high levels of antibodies and neutralizing activity against important virulence factors of EHEC O157, this drug has potential use in the treatment of diarrhea and the prevention of EHEC-associated hemolytic uremic syndrome.

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收藏

页码：378 / 383

页数：6

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