The C-terminal ester of membrane anchored peptide ion channels affects anion transport

被引：20

作者：

Djedovic, N

Ferdani, R

Harder, E

Pajewska, J

Pajewski, R

Schlesinger, PH

Gokel, GW

机构：

[1] Washington Univ, Sch Med, Dept Chem, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Dept Cell Biol, St Louis, MO 63110 USA

[4] Washington Univ, Sch Med, Dept Physiol, St Louis, MO 63110 USA

[5] Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA

来源：

CHEMICAL COMMUNICATIONS | 2003年 / 23期

关键词：

D O I：

10.1039/b312209n

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Five heptapeptide derivatives, [CH3(CH2)(17)](2)NCO-CH2OCH2CO-Gly- Gly- Gly- Pro- Gly- Gly- Gly- OR, in which R = ethyl, 2- propyl, heptyl, benzyl, and cyclohexylmethyl, were found to transport chloride anion through a phospholipid bilayer to varying extents dependent on the identity of R. It was concluded that the R group is a membrane anchor for the synthetic chloride channels.

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收藏

页码：2862 / 2863

页数：2

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