Recent developments for the efficient crystallographic refinement of macromolecular structures

被引：79

作者：

Brünger, AT ^{[1
]}

Adams, PD

Rice, LM

机构：

[1] Yale Univ, Howard Hughes Med Inst, New Haven, CT 06511 USA

[2] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06511 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1998年 / 8卷 / 05期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0959-440X(98)80152-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Macromolecular crystallographic refinement has recently been made more efficient by the use of cross-validated maximum likelihood targets and torsion-angle molecular dynamics simulated annealing, In combination with automated model building methods, the amount of manual intervention required to complete and refine a structure is greatly reduced.

引用

页码：606 / 611

页数：6

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