Function of RNA-binding protein Musashi-1 in stem cells

被引：331

作者：

Okano, H ^{[1
]}

Kawahara, H ^{[1
]}

Toriya, M ^{[1
]}

Nakao, K ^{[1
]}

Shibata, S ^{[1
]}

Imai, T ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Physiol, Shinjuku Ku, Tokyo 1608582, Japan

来源：

EXPERIMENTAL CELL RESEARCH | 2005年 / 306卷 / 02期

关键词：

Musashi; translational regulation; neural stem cell; intestinal stem cell; mammary gland stem cell; notch signaling; numb;

D O I：

10.1016/j.yexcr.2005.02.021

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Musashi is an evolutionarily conserved family of RNA-binding proteins that is preferentially expressed in the nervous system. The first member of the Musashi family was identified in Drosophila. This protein plays an essential role in regulating the asymmetric cell division of ectodermal precursor cells known as sensory organ precursor cells through the translational regulation of target mRNA. In the CNS of Drosophila larvae, however, Musashi is expressed in proliferating neuroblasts and likely has a different function. Its probable mammalian homologue, Musashi-1, is a neural RNA-binding protein that is strongly expressed in fetal and adult neural stem cells (NSCs). Mammalian Musashi-1 augments Notch signaling through the translational repression of its target mRNA, m-Numb, thereby contributing to the self-renewal of NSCs. In addition to its functions in NSCs, the role of mammalian Musashi-1 protein in epithelial stem cells, including intestinal and mammary gland stem cells, is attracting increasing interest. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：349 / 356

页数：8

共 40 条

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