A practical route for synthesizing a PET ligand containing [18F]fluorobenzene using reaction of diphenyliodonium salt with [18F]F-

被引：52

作者：

Zhang, Ming-Rong ^{[1
]}

Kumata, Katsushi ^{[1
]}

Suzuki, Kazutoshi ^{[1
]}

机构：

[1] Natl Inst Radiol Sci, Radiochem Sect, Dept Mol Probes,Mol Imaging Ctr, Inage Ku, Chiba 2638555, Japan

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 49期

关键词：

D O I：

10.1016/j.tetlet.2007.10.025

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The aim of this study was to develop a practical route for preparing a fluorine-18([F-18]) labelled ligand ([F-18]1) containing [F-18]fluorobenzene ring by employing the reaction of diphenyliodonium salt with [F-18]F-. Diphenyliodonium tosylate (2) was synthesized from tributylphenylstannyl compound (6) with [hydroxy(tosyloxy) iodo] benzene (7). Using this method, [F-18]DAA1106 ([F-18]3a), a positron emission tomography ligand for imaging peripheral-type benzodiazepine receptor, was prepared. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：8632 / 8635

页数：4

共 15 条

[1]

ADAM MJ, 1986, J NUCL MED, V27, P1462

[2] An ab initio and MNDO-d SCF-MO computational study of stereoelectronic control in extrusion reactions of R2I-F iodine(III) intermediates [J].