Expression of Wnt genes in human colon cancers

被引：29

作者：

Dimitriadis, A

Vincan, E

Mohammed, IM

Roczo, N

Phillips, WA

Baindur-Hudson, S

机构：

[1] Victoria Univ, Sch Life Sci & Technol, Melbourne, Vic 8001, Australia

[2] Peter MacCallum Canc Inst, Trescowthick Res Labs, Melbourne, Vic 3002, Australia

来源：

CANCER LETTERS | 2001年 / 166卷 / 02期

关键词：

Wnt genes; polymerase chain reaction; colorectal cancer; colon tumorigenesis;

D O I：

10.1016/S0304-3835(01)00428-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A polymerase chain reaction-based approach was used to study the expression of Wnt genes in human colon carcinoma tissue and normal colon mucosa. In a number of cases Wnts 2, 4, 5a, 6 and/or 7a were found to be more highly expressed in colon carcinoma tissue compared to surrounding normal-appealing mucosa from the same patients. Wnts 4, 5a, 6 and 7a, but not 2, were also found to be expressed in colon cancer cell lines. The increased levels of expression of these Wnt genes in tumor tissue may indicate their possible involvement in human colon tumorigenesis. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：185 / 191

页数：7

共 37 条

[1] Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q121 [J].