Rb-mediated chromatin structure regulation and transcriptional repression

There is mounting evidence that interaction with chromatin-modifying co-repressors is important for the regulation of cell cycle progression by members of the Rb family. It appears that distinct remodeling complexes may be responsible for regulating activity of different subsets of cell cycle control genes. Experiments designed to further examine this notion and to use model genetic organisms to study Rb and E2F family function should provide additional evidence about molecular mechanisms through which these families regulate cell cycle progression.