Modulation of the microbial ecology of the human colon by probiotics, prebiotics and synbiotics to enhance human health: An overview of enabling science and potential applications

被引:237
作者
Rastall, RA
Gibson, GR
Gill, HS
Guarner, F
Klaenhammer, TR
Pot, B
Reid, G
Rowland, IR
Sanders, ME
机构
[1] Univ Reading, Sch Food Biosci, Reading RG6 6AP, Berks, England
[2] Dept Primary Ind, Werribee, Vic, Australia
[3] Univ Hosp Vall Hebron, Digest Syst Res Unit, Barcelona, Spain
[4] N Carolina State Univ, Dept Food Sci, Raleigh, NC 27695 USA
[5] Inst Pasteur, F-59019 Lille, France
[6] Univ Western Ontario, Lawson Res Inst, London, ON N6A 3K7, Canada
[7] Univ Ulster, No Ireland Ctr Food & Hlth, Coleraine BT52 1SA, Londonderry, North Ireland
[8] Dairy & Food Culture Technol, Centennial, CO USA
关键词
probiotics; prebiotics; synbiotics; colonic microbiota;
D O I
10.1016/j.femsec.2005.01.003
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The application of probiotics and prebiotics to the manipulation of the microbial ecology of the human colon has recently seen many scientific advances. The sequencing of probiotic genomes is providing a wealth of new information on the biology of these microorganisms. In addition, we are learning more about the interactions of probiotics with human cells and with pathogenic bacteria. An alternative means of modulating the colonic microbial community is by the use of prebiotic oligosaccharides. Increasing knowledge of the metabolism of prebiotics by probiotics is allowing us to consider specifically targeting such dietary intervention tools at specific populatiori groups and specific disease states. (c) 2005 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:145 / 152
页数:8
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