Developmental amnesia: Effect of age at injury

被引:107
作者
Vargha-Khadem, F
Salmond, CH
Watkins, KE
Friston, KJ
Gadian, DG
Mishkin, M [1 ]
机构
[1] NIMH, Bethesda, MD 20892 USA
[2] McGill Univ, Inst Neurol, Montreal, PQ H3A 1S2, Canada
[3] UCL, Inst Child Hlth, London WC1N 3JH, England
[4] UCL, Inst Neurol, London WC1N 3JH, England
[5] Univ Cambridge, Wolfson Brain Imaging Ctr, Cambridge CB2 3EB, England
关键词
D O I
10.1073/pnas.1233756100
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Hypoxic-ischemic events sustained within the first year of life can result in developmental amnesia, a disorder characterized by markedly impaired episodic memory and relatively preserved semantic memory, in association with medial temporal pathology that appears to be restricted to the hippocampus. Here we compared children who had hypoxic-ischemic events before 1 year of age (early group, n = 6) with others who showed memory problems after suffering hypoxic-ischemic events between the ages of 6 and 14 years (late group, n = 5). Morphometric analyses of the whole brain revealed that, compared with age-matched controls, both groups had bilateral abnormalities in the hippocampus, putamen, and posterior thalamus, as well as in the right retrosplenial cortex. The two groups also showed similar reductions (approximate to40%) in hippocampal volumes. Neuropsychologically, the only significant differences between the two were on a few tests of immediate memory, where the early group surpassed the late group. The latter measures provided the only clear indication that very early injury can lead to greater functional sparing than injury acquired later in childhood, due perhaps to the greater plasticity of the infant brain. On measures of long-term memory, by contrast, the two groups had highly similar profiles, both showing roughly equivalent preservation of semantic memory combined with marked impairment in episodic memory. It thus appears that, if this selective memory disorder is a special syndrome related to the early occurrence of hypoxia-induced damage, then the effective age at injury for this syndrome extends from birth to puberty.
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页码:10055 / 10060
页数:6
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