The molecular principles of N-end rule recognition

被引：45

作者：

Sriram, Shashikanth M. ^{[1
,2
]}

Kwon, Yong Tae ^{[1
,2
,3
]}

机构：

[1] Univ Pittsburgh, Ctr Pharmacogenet, Pittsburgh, PA 15260 USA

[2] Univ Pittsburgh, Sch Pharm, Dept Pharmaceut Sci, Pittsburgh, PA 15261 USA

[3] Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Dept Mol Med & Biopharmaceut Sci, Seoul, South Korea

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2010年 / 17卷 / 10期

关键词：

ADAPTER PROTEIN CLPS; E3 UBIQUITIN LIGASES; CARDIOVASCULAR DEVELOPMENT; ESCHERICHIA-COLI; PATHWAY; SUBSTRATE; UBR1; DEGRADATION; COMPONENTS; BINDING;

D O I：

10.1038/nsmb1010-1164

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The N-end rule pathway is a proteolytic system in which recognition components (N-recognins) recognize a set of N-terminal residues as part of degradation signals (N-degrons). Two studies in this issue report the structures of Ubr boxes, a substrate recognition domain of eukaryotic N-recognins. We discuss how eukaryotic and prokaryotic N-recognins use a similar molecular principle to recognize a different set of N-degrons.

引用

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页码：1164 / 1165

页数：2

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