Age-related effects on induction of DNA strand breaks by intermittent exposure to electromagnetic fields

被引：38

作者：

Ivancsits, S ^{[1
]}

Diem, E ^{[1
]}

Jahn, O ^{[1
]}

Rüdiger, HW ^{[1
]}

机构：

[1] Univ Vienna, Div Occupat Med, Univ Hosp, AKH, A-1090 Vienna, Austria

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2003年 / 124卷 / 07期

关键词：

ageing; ELF-EMF exposure; comet assay; fibroblasts;

D O I：

10.1016/S0047-6374(03)00125-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Several studies indicating a decline of DNA repair efficiency with age raise the question, if senescence per se leads to a higher susceptibility to DNA damage upon environmental exposures. Cultured fibroblasts of six healthy donors of different age exposed to intermittent ELF-EMF (50 Hz sinus, 1 mT) for 1-24 h exhibited different basal DNA strand break levels correlating with age. The cells revealed a maximum response at 15-19 h of exposure. This response was clearly more pronounced in cells from older donors, which could point to an age-related decrease of DNA repair efficiency of ELF-EMF induced DNA strand breaks. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：847 / 850

页数：4

共 29 条

[1] THE EFFECT OF VARIOUS ANTIOXIDANTS AND OTHER MODIFYING AGENTS ON OXYGEN-RADICAL-GENERATED DNA-DAMAGE IN HUMAN-LYMPHOCYTES IN THE COMET ASSAY [J].

ANDERSON, D ;

YU, TW ;

PHILLIPS, BJ ;

SCHMEZER, P .

MUTATION RESEARCH, 1994, 307 (01) :261-271

[2]

Ben Yehuda A, 2000, MECH AGEING DEV, V121, P173

[3] DNA-DAMAGE, MUTATION AND FINE-STRUCTURE DNA-REPAIR IN AGING [J].

BOHR, VA ;

ANSON, RM .

MUTATION RESEARCH-DNAGING GENETIC INSTABILITY AND AGING, 1995, 338 (1-6) :25-34

[4] Repair of oxidative DNA damage in nuclear and mitochondrial DNA, and some changes with aging in mammalian cells [J].

Bohr, VA .

FREE RADICAL BIOLOGY AND MEDICINE, 2002, 32 (09) :804-812

[5] Attenuation of DNA polymerase β-dependent base excision repair and increased DMS-induced mutagenicity in aged mice [J].

Cabelof, DC ;

Raffoul, JJ ;

Yanamadala, S ;

Ganir, C ;

Guo, Z ;

Heydari, AR .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2002, 500 (1-2) :135-145

[6] Basal levels of DNA strand breaks in human leukocytes determined by comet assay [J].

Diem, E ;

Ivancsits, S ;

Rüdiger, HW .

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A, 2002, 65 (09) :641-648

[7]

FENECH M, 1985, MUTAT RES, V148, P99, DOI 10.1016/0027-5107(85)90212-X

[8]

GANGULY BB, 1993, MUTAT RES, V295, P135

[9] Mechanisms and implications of the age-associated decrease in DNA repair capacity [J].

Goukassian, D ;

Gad, F ;

Yaar, M ;

Eller, MS ;

Nehal, US ;

Gilchrest, BA .

FASEB JOURNAL, 2000, 14 (10) :1325-1334

[10] Differential display analysis of gene expression indicates that age-related changes are restricted to a small cohort of genes [J].

Goyns, MH ;

Charlton, MA ;

Dunford, JE ;

Lavery, WL ;

Merry, BJ ;

Salehi, M ;

Simoes, DDC .

MECHANISMS OF AGEING AND DEVELOPMENT, 1998, 101 (1-2) :73-90

← 1 2 3 →