Experimental Infection of Young Adult European Breed Sheep with Rift Valley Fever Virus Field Isolates

被引：50

作者：

Busquets, Nuria ^{[2
]}

Xavier, F. ^{[2
]}

Martin-Folgar, Raquel ^{[1
]}

Lorenzo, Gema ^{[1
]}

Galindo-Cardiel, Ivan ^{[2
]}

Perez del Val, Bernat ^{[2
]}

Rivas, Raquel ^{[2
]}

Iglesias, Javier ^{[1
]}

Rodriguez, Fernando ^{[2
]}

Solanes, David ^{[2
]}

Domingo, Mariano ^{[2
]}

Brun, Alejandro ^{[1
]}

机构：

[1] INIA, CISA, Ctr Invest Sanidad Anim, Valdeolmos 28130, Spain

[2] UAB IRTA, Ctr Recerca Sanitat Anim, CReSA, Bellaterra, Spain

来源：

VECTOR-BORNE AND ZOONOTIC DISEASES | 2010年 / 10卷 / 07期

关键词：

Experimental infection; European lambs; Immune response; Rift Valley fever virus; Viral transmission; VACCINE; OUTBREAK;

D O I：

10.1089/vbz.2009.0205

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The increasing interest in Rift Valley fever virus (RVFV) and its potential impact on naive animal populations deserve revisiting experimental reproduction of RVFV infection, particularly in those animal breeds for which no data about their susceptibility to RVFV infection have ever been recorded. In this study we show the susceptibility of 9-10 weeks old European sheep (Ripollesa breed) to RVFV infection, showing a mild, subacute form of disease. Four different viral isolates efficiently replicated in vivo after subcutaneous experimental inoculation, and consistent viral loads in blood and virus shedding (variable in length depending on the RVFV isolate used) were detected, showing horizontal transmission to a noninfected, sentinel lamb. RVFV infection caused transient pyrexia in adult lambs and no other clinical symptoms were observed, with the exception of corneal opacity ("blue eye") found in 3 out of 16 subcutaneously inoculated sheep. In conclusion, adult sheep from this European breed are readily infected with RVFV without apparent clinical manifestations.

引用

页码：689 / 696

页数：8

共 33 条

[1] More deaths from Rift Valley fever in Saudi Arabia and Yemen [J].

Ahmad, K .

LANCET, 2000, 356 (9239) :1422-1422

[2] Ocular complications of Rift Valley fever outbreak in Saudi Arabia [J].

Al-Hazmi, A ;

Al-Rajhi, AA ;

Abboud, EB ;

Ayoola, EA ;

Al-Hazmi, M ;

Saadi, R ;

Ahmed, N .

OPHTHALMOLOGY, 2005, 112 (02) :313-318

[3] VIRAL DETERMINANTS OF VIRULENCE FOR RIFT-VALLEY FEVER (RVF) IN RATS [J].

ANDERSON, GW ;

PETERS, CJ .

MICROBIAL PATHOGENESIS, 1988, 5 (04) :241-250

[4]

[Anonymous], 2008, Wkly Epidemiol Rec, V83, P17

[5]

[Anonymous], 2007, Wkly Epidemiol Rec, V82, P169

[6] Prediction of a Rift Valley fever outbreak [J].

Anyamba, Assaf ;

Chretien, Jean-Paul ;

Small, Jennifer ;

Tucker, Compton J. ;

Formenty, Pierre B. ;

Richardson, Jason H. ;

Britch, Seth C. ;

Schnabelf, David C. ;

Erickson, Ralph L. ;

Linthicum, Kenneth J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (03) :955-959

[7]

BARNARD BJH, 1977, J S AFR VET ASSOC, V48, P45

[8] ANTIGENIC ANALYSIS OF RIFT-VALLEY FEVER VIRUS ISOLATES - MONOCLONAL-ANTIBODIES DISTINGUISH BETWEEN WILD-TYPE AND NEUROTROPIC VIRUS-STRAINS [J].

BESSELAAR, TG ;

BLACKBURN, NK ;

MEENEHAN, GM .

RESEARCH IN VIROLOGY, 1991, 142 (06) :469-474

[9] Complete genome ancalysis of 33 ecologically and biologically diverse rift valley fever virus strains reveals widespread virus movement and low genetic diversity due to recent common ancestry [J].

Bird, Brian H. ;

Khristova, Marina L. ;

Rollin, Pierre E. ;

Ksiazek, Thomas G. ;

Nichol, Stuart T. .

JOURNAL OF VIROLOGY, 2007, 81 (06) :2805-2816

[10]

EASTERDAY BC, 1962, AM J VET RES, V23, P470

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