Highly regioselective palladium-catalyzed internal arylation of allyltrimethylsilane with aryl triflates

被引：64

作者：

Olofsson, K ^{[1
]}

Larhed, M ^{[1
]}

Hallberg, A ^{[1
]}

机构：

[1] Univ Uppsala, Ctr Biomed, Dept Organ Pharmaceut Chem, SE-75123 Uppsala, Sweden

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1998年 / 63卷 / 15期

关键词：

D O I：

10.1021/jo980249n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Highly regioselective ligand-controlled Heck-arylation reactions of allyltrimethylsilane, delivering branched beta-products, were performed in moderate to good yields. The high preference for internal over terminal double-bond arylation suggests a contribution from the beta-cation-stabilizing effect of silicon. Microwave-promoted palladium-catalyzed coupling reactions proceeded with the same regioselectivity in six entries out of eight with the reaction times cut sharply down to 5-10 min.

引用

页码：5076 / 5079

页数：4

共 72 条

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