Mesalazine release from a pH dependent formulation: effects of omeprazole and lactulose co-administration

被引：10

作者：

Hussain, FN ^{[1
]}

Ajjan, RA ^{[1
]}

Moustafa, M ^{[1
]}

Weir, NW ^{[1
]}

Riley, SA ^{[1
]}

机构：

[1] No Gen Hosp, Dept Gastroenterol, Sheffield S5 7AU, S Yorkshire, England

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1998年 / 46卷 / 02期

关键词：

delayed-release mesalazine; omeprazole; lactulose; pH-dependent drug delivery; ulcerative colitis;

D O I：

10.1046/j.1365-2125.1998.00762.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aims Delayed-release formulations of mesalazine often rely on the gastrointestinal luminal pH profile to deliver 5-aminosalicylic acid (5ASA) to the colon. The aim of this study was to examine the influence of luminal pH on mesalazine release. Methods We studied, the effect of co-administration of omeprazole and lactulose on the steady-state pharmacokinetics of Eudragit S-coated mesalazine in healthy volunteers. Results No significant changes in urinary or faecal levels of 5ASA or its main metabolite, N-acetyl 5ASA, were apparent. Conclusions This study suggests that co-administration of omeprazole and lactulose does not impair the release of delayed-release mesalazine.

引用

页码：173 / 175

页数：3

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