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Telomerase and cancer

被引：339
作者：
Shay, JW
Zou, Y
Hiyama, E
Wright, WE
机构：
[1] Univ Texas, SW Med Ctr, Dept Cell Biol, Dallas, TX 75390 USA
[2] Hiroshima Univ, Sch Med, Dept Gen Med, Hiroshima, Japan
来源：
HUMAN MOLECULAR GENETICS | 2001年 / 10卷 / 07期
关键词：
D O I：
10.1093/hmg/10.7.677
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Telomerase, a eukaryotic ribonucleoprotein (RNP) complex, contains both an essential RNA and a protein reverse transcriptase subunit, By reverse transcription, the telomerase RNP maintains telomere length stability in almost all cancer cells. Over the past few years there has been significant progress in identifying the components of the telomerase holoenzyme complex and the proteins that associate with telomeres, in order to elucidate mechanisms of telomere length regulation. This review covers recent advances in the field including the use of telomerase in cancer diagnostics and an overview of anti-telomerase cancer therapeutic approaches.
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页码：677 / 685
页数：9
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