Prions as adaptive conduits of memory and inheritance

被引：404

作者：

Shorter, J ^{[1
]}

Lindquist, S ^{[1
]}

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

来源：

NATURE REVIEWS GENETICS | 2005年 / 6卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrg1616

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Changes in protein conformation drive most biological processes, but none have seized the imagination of scientists and the public alike as have the self-replicating conformations of prions. Prions transmit lethal neurodegenerative diseases by means of the food chain. However, self-replicating protein conformations can also constitute molecular memories that transmit genetic information. Here, we showcase definitive evidence for the prion hypothesis and discuss examples in which prion-encoded heritable information has been harnessed during evolution to confer selective advantages. We then describe situations in which prion-enciphered events might have essential roles in long-term memory formation, transcriptional memory and genome-wide expression patterns.

引用

收藏

页码：435 / 450

页数：16

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