Enhancing effects of alpha,beta-monoglycosylceramides on natural killer cell activity

被引：58

作者：

Kobayashi, E ^{[1
]}

Motoki, K ^{[1
]}

Yamaguchi, Y ^{[1
]}

Uchida, T ^{[1
]}

Fukushima, H ^{[1
]}

Koezuka, Y ^{[1
]}

机构：

[1] KIRIN BREWERY CO LTD,PHARMACEUT RES LAB,TAKASAKI,GUMMA 37012,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1996年 / 4卷 / 04期

关键词：

KRN7000; natural killer cells; galactosylceramide; glycosylceramide; immunomodulator;

D O I：

10.1016/0968-0896(96)00049-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We examined in vitro and in vivo natural killer (NK) cell activity enhancing effects of alpha-, beta-galactosylceramide (GalCer) and alpha-, beta-glucosylceramide (GluCer) which have the same ceramide moiety, and of other alpha-, beta-GalCer having a different ceramide portion, and found that alpha-types show stronger enhancing effects than beta-types and the alpha-GalCer possesses the most potent activity among GalCers and GluCers having the same ceramide moiety. When the comparison of tumor growth inhibitory effects of alpha-, beta-GalCer on mice subcutaneously inoculated with B16 cells was performed, the alpha-GalCer showed stronger suppressive activity than its beta-type, paralleling their enhancing effects on NK cell activity. These results suggest that the manner of combination between sugar and ceramide plays an important role in antitumor activity as well as enhancing effect on NK cell activity of GalCers. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：615 / 619

页数：5

共 16 条

[1]

ENDO M, 1986, PURE APPL CHEM, P387

[2] NATURAL-KILLER CELLS - THEIR ROLE IN DEFENSES AGAINST DISEASE [J].

HERBERMAN, RB ;

ORTALDO, JR .

SCIENCE, 1981, 214 (4516) :24-30

[3]

HIGUCHI R, 1990, LIEBIGS ANN CHEM, P51

[4]

HIGUCHI R, 1990, LIEBIGS ANN CHEM, P659

[5]

HIRSCH S, 1989, TETRAHEDRON, V45, P3897, DOI 10.1016/S0040-4020(01)89249-8

[6] SPHINGOLIPID COMPOSITION OF BOVINE KIDNEY-CORTEX, MEDULLA AND PAPILLA [J].

KARLSSON, KA ;

SAMUELSSON, BE ;

STEEN, GO .

BIOCHIMICA ET BIOPHYSICA ACTA, 1973, 316 (03) :317-335

[7]

KARUPIAH G, 1990, J IMMUNOL, V144, P290

[8]

KAWANO Y, 1988, LIEBIGS ANN CHEM, P19

[9]

Kobayashi E, 1995, ONCOL RES, V7, P529

[10] STRUCTURE-ACTIVITY RELATIONSHIP OF ALPHA-GALACTOSYLCERAMIDES AGAINST B16-BEARING MICE [J].

MORITA, M ;

MOTOKI, K ;

AKIMOTO, K ;

NATORI, T ;

SAKAI, T ;

SAWA, E ;

YAMAJI, K ;

KOEZUKA, Y ;

KOBAYASHI, E ;

FUKUSHIMA, H .

JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (12) :2176-2187

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